Telomeres相关论文
cGAS guards against chromosome end-to-end fusions during mitosis and facilitates replicative senesce
As a sensor of cytosolic DNA,the role of cyclic GMP-AMP synthase (cGAS) in innate immune response is well established,ye......
端粒是真核细胞维持自身染色体稳定的重要成分，其 DNA 序列位于染色体的末端，端粒的长度会随着染色体的不完全复制和细胞分裂而逐渐......
,Estrogen deficiency reversibly induces telomere shortening in mouse granulosa cells and ovarian agi
Estrogen is implicated as playing an important role in aging and tumorigenesis of estrogen responsive tissues;however th......
,TGF-beta receptor mediated telomerase inhibition, telomere shortening and breast cancer cell senesc
Human telomerase reverse transcriptase (hTERT) plays a central role in telomere lengthening for continuous cell prolifer......
While the majority of all human cancers counteract telomere shortening by expressing telomerase,～15％ of all cancers mainta......
,Recombination-Independent Mechanisms and Pairing of Homologous Chromosomes during Meiosis in Plants
...
从衰老机理的角度深入探讨了人类首例克隆动物“多利”的实际年龄及预期寿命。强调了生理功能和其它寿命指数应该比染色体中的端粒......
目的:研究食管癌组织中端粒酶活性检测的临床意义,探讨其作为食管癌诊断和预后评价指标的可行性.方法:采用端粒重复序列扩增(telom......
Mechanisms of cell immortalization mediated by EB viral activation of telomerase in nasopharyngeal c
鼻咽的癌(NPC ) 是在南部的中国和东南亚洲的普通癌症。没有有效痊愈，疾病是糟糕区分的癌，并且位于它的发展下面的机制仍然保持大部......
Estrogen deficiency leads to telomerase inhibition, telomere shortening and reduced cell proliferati
雌激素缺乏调停变老，但是内在的机制尚待充分坚定。我们这里报导 aromatase 的指向的混乱在老鼠引起的雌激素缺乏在 vivo 在肾上腺......
端粒是染色体末端独特的DNA-蛋白质结构,其主要作用为保护染色体的完整性和维持细胞的复制能力.端粒酶是由RNA和蛋白质亚基构成的,......
端粒是真核生物染色体末端由许多简单重复序列和相关蛋白组成的复合结构，具有维持染色体结构完整性的作用。端粒有随着细胞分裂次数......
端粒是染色体末端由重复DNA序列和相关蛋白组成的一种特殊结构,具有稳定染色体结构及完整性的功能,会随染色体复制与细胞分裂而缩......
期刊
端粒是真核细胞线性染色体末端的DNA重复序列和特异结合蛋白的复合体,对维持染色体的稳定性和完整性具有重要作用.端粒酶是一种由R......
目的：观察补肾中药复方首参颗粒对动脉粥样硬化（atherosclerosis, AS）模型大鼠血管细胞与外周血白细胞端粒、端粒酶以及动脉壁病变、......
端粒和端粒酶是现代生物学研究的热点,端粒的缺失与细胞的衰老,端粒酶的活性与细胞的老化及癌化均有密切的关系.文章综述了端粒和......
[目的]探讨放射线对人舌鳞癌细胞系Tca8113端粒长度变化的影响.[方法]采用流式原位杂交法(FLOW-FISH)检测Tca8113细胞的端粒相对长......
目的研究端粒长度、端粒酶逆转录酶(TERT)和端粒保护蛋白1(POT1)在阿尔茨海默病大鼠外周血中的表达情况。分析阿司匹林对AD大鼠模......
端粒是真核细胞维持自身染色体稳定的重要成分,其DNA序列位于染色体的末端,端粒的长度会随着染色体的不完全复制和细胞分裂而逐渐......
端粒是现代生物学研究的热点,端粒封闭了染色体的末端并维持了染色体的稳定性,端粒的缺失与细胞的衰老有密切的关系。本文就端粒的......
Amniotic fluid stem cells(AFSC) are noncontroversial and abundant potentially transplantable cells. They are derived fro......
The restriction endonuclease Tru9I is a useful tool to analyze telomere sequences separately from in
We have previously described a simple method to analyze the chromatin structure of Arabidopsis telomeres independently o......
端粒在细胞的生理病理过程中起到至关重要的作用。端粒末端有一段富含鸟嘌呤（G）的单链DNA重复序列,该序列在单价金属离子如Na＋或K＋作用......
...
Colorectal cancer is the third most common form of cancer and the second leading cause of cancer-related death in the we......
Telomeres are DNA-protein structures that form protective caps at the end of eukaryotic chromosomes,safeguarding the chr......
Five theories shed lights on the potential mechanisms of aging:somatic mutations,telomere loss,mitochondrial defects,and......
本工作回顾了端粒的基本特征并特别强调端粒与有机体辐射敏感性的关系及其在放射生物学中的潜在重要性。研究结果显示，端粒长度的改......
Recent advances in reprograming somatic cells from normal and diseased tissues into induced pluripotent stem cells (iPSC......
采用中性溶菌结合超速离心的方法，从链霉菌ＦＲ－００８中直接提取了完整的１３０ｋｂ的大一质粒ＰＨＺ２２７，经蛋白酶Ｋ和限制性内切酶处理后，进行强迫克隆，生内切酶酶解和......
